tubocurarine

Ligand id: 2294

Name: tubocurarine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 80.62
Molecular weight 609.3
XLogP 4.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Historically used adjunctively in anaesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. All formulations of this drug formerly approved by the US FDA appear to have been discontinued. Other national approval agencies may have granted marketing authorisation. Newer and improved drugs are now available.
Mechanism Of Action and Pharmacodynamic Effects
Tubocurarine is a long-acting antagonist of muscle-type nicotinic acetylcholine receptors (subunit composition (α1)2β1δε or (α1)2β1δγ) [12]). Full details of the subunits are available via the Nicotinic acetylcholine receptors page of this website.