cisapride

Ligand id: 240

Name: cisapride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 86.05
Molecular weight 465.18
XLogP 2.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cisapride is used to treat motility related gastrointestinal disorders such as gastroesophageal reflux disease.
Mechanism Of Action and Pharmacodynamic Effects
Cisapride is a serotonin 4 (5-HT4) receptor agonist which increases acetylcholine release, resulting in a combination of effects which culminate in accelerated gastric emptying and intestinal transit (eg increased tone and amplitude of gastric contractions, relaxation of the pyloric sphincter, increased duodenal and jejunal peristalsis).