nicorandil

Ligand id: 2411

Name: nicorandil

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nicorandil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 94.36
Molecular weight 211.06
XLogP 0.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Nicorandil is not approeved by the US FDA or EMA. Individual national approval agencies have authorised marketing of this drug. Nicorandil is used to treat chronic stable angina pectoris.
Mechanism Of Action and Pharmacodynamic Effects
Nicorandil has dual properties, acting as a nitrate and as a K+ATP channel agonist. At low plasma concentrations the nitrate action dilates the large coronary arteries, and at high plasma concentrations nicorandil induces K+ATP channel opening which reduces coronary vascular resistance [1]. These actions combine to provide cardioprotective effects.
External links