prucalopride

Ligand id: 243

Name: prucalopride

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 76.82
Molecular weight 367.17
XLogP 0.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Prucalopride is approved to treat symptoms of chronic constipation in women for whom laxatives are not effective.
Mechanism Of Action and Pharmacodynamic Effects
The 5-HT4 receptor subtype is physiologically and pathophysiologically important for the regulation of intestinal peristalsis and gut motility [1,6-7]. Activation of these receptors in the gut wall enhances the peristaltic reflex [4], relaxes the smooth muscle and increases fluid secretion in the gastrointestinal (GI) tract [5]. All of these actions improve transit in GI functional disorders.