prucalopride

Ligand id: 243

Name: prucalopride

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 76.82
Molecular weight 367.17
XLogP 0.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Baker DE. (2005)
Rationale for using serotonergic agents to treat irritable bowel syndrome.
Am J Health Syst Pharm62 (7): 700-11; quiz 712-3. [PMID:15790796]
2. Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W. (2000)
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
J Neurochem.74: 478-489. [PMID:10646498]
3. Briejer MR, Bosmans JP, Van Daele P, Jurzak M, Heylen L, Leysen JE, Prins NH, Schuurkes JA. (2001)
The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.
Eur J Pharmacol423: 71-83. [PMID:11438309]
4. Gershon MD, Tack J. (2007)
The serotonin signaling system: from basic understanding to drug development for functional GI disorders.
Gastroenterology132 (1): 397-414. [PMID:17241888]
5. Hansen MB, Skadhauge E. (1997)
Signal transduction pathways for serotonin as an intestinal secretagogue.
Comp. Biochem. Physiol. A Physiol.118 (2): 283-90. [PMID:9366057]
6. Kadowaki M, Wade PR, Gershon MD. (1996)
Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon.
Am. J. Physiol.271 (5 Pt 1): G849-57. [PMID:8944700]
7. Kim DY, Camilleri M. (2000)
Serotonin: a mediator of the brain-gut connection.
Am. J. Gastroenterol.95 (10): 2698-709. [PMID:11051338]