nifedipine

Ligand id: 2514

Name: nifedipine

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View more information in the IUPHAR Pharmacology Education Project: nifedipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 107.77
Molecular weight 346.12
XLogP 3.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon.
Mechanism Of Action and Pharmacodynamic Effects
Nifedipine inhibits the influx of calcium ions through L-type calcium channels leading to decreased arterial smooth muscle contraction and vasoconstricton. For a complete overview of the mechanism of action of nifedipine, please see the DrugBank entry linked to from this ligand page.
External links