nifedipine

Ligand id: 2514

Name: nifedipine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 107.77
Molecular weight 346.12
XLogP 3.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
Proc. Natl. Acad. Sci. U.S.A.95 (21): 12208-13. [PMID:9770465]
2. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. (1994)
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol. Pharmacol.45 (6): 1227-34. [PMID:7517498]
3. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. (1998)
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
J. Biol. Chem.273 (10): 5851-7. [PMID:9488722]
4. Lamb GD, Walsh T. (1987)
Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.
J. Physiol. (Lond.)393: 595-617. [PMID:2451745]
5. McRory JE, Hamid J, Doering CJ, Garcia E, Parker R, Hamming K, Chen L, Hildebrand M, Beedle AM, Feldcamp L, Zamponi GW, Snutch TP. (2004)
The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution.
J. Neurosci.24 (7): 1707-18. [PMID:14973233]
6. Pignier C, Potreau D. (2000)
Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytes.
Am. J. Physiol. Heart Circ. Physiol.279 (5): H2259-68. [PMID:11045961]
7. Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J. (2009)
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Mol. Pharmacol.75 (2): 407-14. [PMID:19029287]