Ligand Id: 2514
Ligand name nifedipine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 107.77
Molecular weight 346.12
XLogP 3.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Lamb, GD; Walsh, T. (1987)
Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.
J. Physiol. (Lond.), 393: 595-617. [PMID:2451745]
2. Liao, P; Yu, D; Li, G; Yong, TF; Soon, JL; Chua, YL; Soong, TW. (2007)
A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine.
J. Biol. Chem., 282 (48): 35133-42. [PMID:17916557]
3. Pignier, C; Potreau, D. (2000)
Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytes.
Am. J. Physiol. Heart Circ. Physiol., 279 (5): H2259-68. [PMID:11045961]
4. McRory, JE; Hamid, J; Doering, CJ; Garcia, E; Parker, R; Hamming, K; Chen, L; Hildebrand, M; Beedle, AM; Feldcamp, L; Zamponi, GW; Snutch, TP. (2004)
The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution.
J. Neurosci., 24 (7): 1707-18. [PMID:14973233]
5. Grissmer, S; Nguyen, AN; Aiyar, J; Hanson, DC; Mather, RJ; Gutman, GA; Karmilowicz, MJ; Auperin, DD; Chandy, KG. (1994)
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol. Pharmacol., 45 (6): 1227-34. [PMID:7517498]
6. Kalman, K; Nguyen, A; Tseng-Crank, J; Dukes, ID; Chandy, G; Hustad, CM; Copeland, NG; Jenkins, NA; Mohrenweiser, H; Brandriff, B; Cahalan, M; Gutman, GA; Chandy, KG. (1998)
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
J. Biol. Chem., 273 (10): 5851-7. [PMID:9488722]
7. Bertilsson, G; Heidrich, J; Svensson, K; Asman, M; Jendeberg, L; Sydow-Bäckman, M; Ohlsson, R; Postlind, H; Blomquist, P; Berkenstam, A. (1998)
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
Proc. Natl. Acad. Sci. U.S.A., 95 (21): 12208-13. [PMID:9770465]