mibefradil

Ligand id: 2522

Name: mibefradil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 67.45
Molecular weight 495.29
XLogP 6.43
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug was approved to treat hypertension and chronic angina pectoris, but was withdrawn after only one year due to the risk of potentially fatal effects caused by interaction with other drugs.
Mechanism Of Action and Pharmacodynamic Effects
Mibefradil is a nonselective calcium channel blocker.