Ligand id: 2561

Name: propafenone

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View more information in the IUPHAR Pharmacology Education Project: propafenone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 58.56
Molecular weight 341.2
XLogP 5.52
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the management of atrial arrhythmias to prolong the time between reoccurences of paroxysmal atrial fibrillation/flutter. Also used in the treatment of ventricular arrhythmias.
Mechanism Of Action and Pharmacodynamic Effects
For an overview of the mechanism of action of propafenone, please see the DrugBank entry linked to from this ligand page.
External links