propafenone

Ligand id: 2561

Name: propafenone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 58.56
Molecular weight 341.2
XLogP 5.52
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
β2-adrenoceptor Antagonist Antagonist 7.4 pKi - 1
pKi 7.4 (Ki 3.6x10-8 M) [1]
β1-adrenoceptor Antagonist Antagonist 6.7 pKi - 1
pKi 6.7 (Ki 2.05x10-7 M) [1]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.5 Channel blocker - 4.4 pIC50 - 2
pIC50 4.4 [2]