retigabine

Ligand id: 2601

Name: retigabine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 76.38
Molecular weight 303.14
XLogP 3.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to treat partial-onset epileptic seizures.
Mechanism Of Action and Pharmacodynamic Effects
Retigabine acts as a neuronal voltage activated potassium channel opener but may also affect inhibitory GABA neurotransmission by the GABAA receptor. See the DrugBank link for further details.
External links