Ligand id: 2601

Name: retigabine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 76.38
Molecular weight 303.14
XLogP 3.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Dupuis DS, Schrøder RL, Jespersen T, Christensen JK, Christophersen P, Jensen BS, Olesen SP. (2002)
Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.
Eur. J. Pharmacol., 437 (3): 129-37. [PMID:11890900]
2. Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA. (2000)
Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.
Mol. Pharmacol., 58 (2): 253-62. [PMID:10908292]
3. Rogawski MA, Bazil CW. (2008)
New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels.
Curr Neurol Neurosci Rep, 8 (4): 345-52. [PMID:18590620]
4. Tatulian L, Delmas P, Abogadie FC, Brown DA. (2001)
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.
J. Neurosci., 21 (15): 5535-45. [PMID:11466425]