Ligand id: 2757

Name: meclizine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 6.48
Molecular weight 390.19
XLogP 8.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the management of motion sickness to prevent symptoms of nausea, vomiting and dizziness.
Mechanism Of Action and Pharmacodynamic Effects
An antagonist at histamine H1 receptors, meclizine depresses labyrinth excitability and vestibular stimulation, and also acts as an anticholinergic agent, and central nervous system depressant with local anesthetic effects. However, we have been unable to find affinity data for this drug to substantiate this MMOA.