Ligand id: 2757

Name: meclizine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 6.48
Molecular weight 390.19
XLogP 8.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Huang W, Zhang J, Wei P, Schrader WT, Moore DD. (2004)
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.
Mol. Endocrinol., 18 (10): 2402-8. [PMID:15272053]