cyproheptadine

Ligand id: 277

Name: cyproheptadine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 3.24
Molecular weight 287.17
XLogP 7.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of rhinitis, allergic conjunctivitis, urticaria and as an adjunct to adrenaline for therapy of anaphylactic reactions.
Mechanism Of Action and Pharmacodynamic Effects
The main action of cyproheptadine is to reduce the negative symptoms resulting from histamine receptor activation by endogenous ligand. Cyproheptadine effectively competes with (antagonizes) endogenous histamine for binding at histamine receptors.