cortisol

Ligand id: 2868

Name: cortisol

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: cortisol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 362.21
XLogP 0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Hydrocortisone is used to treat many immune and allergic disorders, adrenal insufficiency disorders (eg Addison's disease) and corticosteroid-responsive dermatological disorders (eg psoriasis, atopic dermatitis, and contact dermatitis).
Mechanism Of Action and Pharmacodynamic Effects
The glucocorticoid receptor-drug complex acts as a transcription factor at glucocorticoid response elements in gene promoter regions, resulting in increased expression of specific target genes. Notably synthesis of prostaglandins and leukotrienes (two of the main pro-inflammatory mediators) is inhibited by the action of glucocorticoids.
External links