Ligand id: 3035

Name: pitavastatin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 90.65
Molecular weight 421.17
XLogP 5.05
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Pitavastatin is used to treat high cholesterol in adults.
Mechanism Of Action and Pharmacodynamic Effects
Like other statins, pitavastatin inhibits HMG CoA reductase (HMGCR) activity. As this enzyme is responsible for catalysing the first step of cholesterol synthesis, its inhibition reduces the amount of cholesterol produced.
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