Ligand id: 357

Name: imipramine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 6.48
Molecular weight 280.19
XLogP 5.24
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Imipramine is used to treat major depressive disorder. The drug is also used to treat panic disorders, ADHD, eating disorders, acute depressive episodes in bipolar disorder and schizophrenia, and neuralgic pain.
Mechanism Of Action and Pharmacodynamic Effects
Imipramine inhibits reuptake of serotonin and norepinephrine by inhibiting the sodium-dependent transporters responsible for their trans-membrane transport (SLC6A4 and SLC6A2 respectively).