Ligand id: 357

Name: imipramine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 6.48
Molecular weight 280.19
XLogP 5.24
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. García-Ferreiro RE, Kerschensteiner D, Major F, Monje F, Stühmer W, Pardo LA. (2004)
Mechanism of block of hEag1 K+ channels by imipramine and astemizole.
J. Gen. Physiol., 124 (4): 301-17. [PMID:15365094]
2. Kobayashi T, Washiyama K, Ikeda K. (2004)
Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Neuropsychopharmacology, 29 (10): 1841-51. [PMID:15150531]
3. Kovacs I, Yamamura HI, Waite SL, Varga EV, Roeske WR. (1998)
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
J Pharmacol Exp Ther, 284: 500-507. [PMID:9454790]
4. Sweetnam PM, Caldwell L, Lancaster J, Bauer Jr C, McMillan B, Kinnier WJ, Price CH. (1993)
The role of receptor binding in drug discovery.
J. Nat. Prod., 56 (4): 441-55. [PMID:8496700]