Ligand id: 4128

Name: amantidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 26.02
Molecular weight 151.14
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Amantidine has historically been used as an antiviral agent to treat influenza, but as the flu virus has become resistant to amantadine this use no longer recommended. The drug may also be used as an antiparkinsonian drug, but again the effectiveness of this treatment has been questioned. The US FDA website has no current approval information for this drug.
Mechanism Of Action and Pharmacodynamic Effects
Amantidine's MMOA in the treatment of Parkinson's symptoms arises from its multifunctional activity. These actions include, antagonism of the NMDA type glutamate receptor, stimulation of increased dopamine release, and inhibition of dopamine reuptake.