nordihydroguiaretic acid

Ligand id: 4265

Name: nordihydroguiaretic acid

Abbreviated name: NDGA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 80.92
Molecular weight 302.15
XLogP 5.06
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of actinic keratoses. The US FDA has discontinued approval for masoprocol.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of masoprocol is unknown, but it is a potent inhibitor of 5-lipoxygenase and has antiproliferative activity against keratinocytes in vitro.