γ-hydroxybutyric acid

Ligand id: 4711

Name: γ-hydroxybutyric acid

Abbreviated name: GHB

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 57.53
Molecular weight 104.05
XLogP -0.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used clinically to reduce excessive daytime sleepiness and cataplexy in patients with narcolepsy. Some countries approve use of sodium oxybate for the management of alcohol dependence.
Mechanism Of Action and Pharmacodynamic Effects
γ-hydroxybutyric acid (GHB) and related compounds primarily act on GABAB receptors to activate potassium channels. This causes neuronal hyperpolarisation, blocks sodium channel opening and prevents firing of action potentials and VGCC (voltage-gated calcium channel) opening. The cumulative effect is a reduction in neurotransmitter release which has an inhibitory effect in the CNS. GHB may also act via SLC52A2 (aka GHB receptor) [2-3].
External links