Ligand id: 4802

Name: fludarabine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 139.54
Molecular weight 285.09
XLogP -1.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of B-cell chronic lymphocytic leukemia in adult patients.
Mechanism Of Action and Pharmacodynamic Effects
The active metabolite is believed to be 2-fluoro-ara-ATP, which appears to act, at least in part, by inhibiting DNA polymerase α, ribonucleotide reductase and DNA primase. This combination of actions inhibits DNA synthesis and leads to cell death.