Ligand id: 4802

Name: fludarabine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 139.54
Molecular weight 285.09
XLogP -1.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S, Barnes K, Ritzel MW, Cass CE, Young JD. (2005)
Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes.
J. Biol. Chem., 280 (16): 15880-7. [PMID:15701636]
2. Larráyoz IM, Fernández-Nistal A, Garcés A, Gorraitz E, Lostao MP. (2006)
Characterization of the rat Na+/nucleoside cotransporter 2 and transport of nucleoside-derived drugs using electrophysiological methods.
Am. J. Physiol., Cell Physiol., 291 (6): C1395-404. [PMID:16837649]
3. Tseng WC, Derse D, Cheng YC, Brockman RW, Bennett Jr LL. (1982)
In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells.
Mol. Pharmacol., 21 (2): 474-7. [PMID:7048062]