reboxetine   Click here for help

GtoPdb Ligand ID: 4808

Synonyms: Edronax® | PNU-165442G
Approved drug
reboxetine is an approved drug
Compound class: Synthetic organic
Comment: Reboxetine is a norepinephrine reuptake inhibitor (NRI) antidepressant. It is ~20-fold selective for the norepinephrine transporter over the serotonin transporter, so at therapeutic doses some inhibition of serotonin uptake is observed.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: reboxetine

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 39.72
Molecular weight 313.17
XLogP 3.07
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCOc1ccccc1OC(c1ccccc1)C1OCCNC1
Isomeric SMILES CCOc1ccccc1O[C@@H](c1ccccc1)[C@H]1OCCNC1
InChI InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m0/s1
InChI Key CBQGYUDMJHNJBX-OALUTQOASA-N
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of clinical depression, panic disorders and ADHD. There is no information regarding marketing authorisation for this drug on the US FDA or EMA websites. Other national approval agencies may have granted marketing approval. For example, the UK granted approval in 1997 for Edronax® for acute treatment of depressive illness/major depression and for maintaining clinical improvement in patients initially responding to treatment.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Selectively inhibits noradrenaline reuptake. Reboxetine is also reported to inhibit brain and cardiac G protein-coupled inwardly-rectifying potassium channels (GIRKs) which may contribute to some of the therapeutic effects of NRIs and adverse side effects related to nervous system and heart function.[1].
External links Click here for help
For extended ADME data see the following:

Electronic Medicines Compendium (eMC)