reboxetine

Ligand id: 4808

Name: reboxetine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 39.72
Molecular weight 313.17
XLogP 4.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Kobayashi T, Washiyama K, Ikeda K. (2010)
Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine.
Neuropsychopharmacology35 (7): 1560-9. [PMID:20393461]
2. Wong EH, Sonders MS, Amara SG, Tinholt PM, Piercey MF, Hoffmann WP, Hyslop DK, Franklin S, Porsolt RD, Bonsignori A et al.. (2000)
Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor.
Biol. Psychiatry47 (9): 818-29. [PMID:10812041]