letrozole

Ligand id: 5209

Name: letrozole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 78.29
Molecular weight 285.1
XLogP 3.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.
Mechanism Of Action and Pharmacodynamic Effects
Aromatase (CYP19A1) inhibitors suppress the aromatization of androgens into estrogens. In postmenopausal women this action can have an anti-proliferative effect on the growth of estrogen-responsive cancers.