CHIR-265

Ligand id: 5674

Name: CHIR-265

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 80.65
Molecular weight 518.13
XLogP 7.09
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A single Phase II clinical trial of RAF265 in metastatic melanoma (NCT00304525) has been completed. Development of this compound has not progressed beyond Phase II.