Ligand id: 6374

Name: benazepril

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: benazepril

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 95.94
Molecular weight 424.2
XLogP 6.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Angiotensin-converting-enzyme inhibitor (ACE inhibitor) used to treat hypertension, congestive heart failure and chronic renal failure.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of ACE acts on the renin-angiotensin-aldosterone system (RAAS) to relax blood vessels which leads to a reduction in blood pressure.
The ester group is cleaved in the liver, converting benazepril into its active form benazeprilat.