Ligand id: 6453

Name: trandolapril

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View more information in the IUPHAR Pharmacology Education Project: trandolapril

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 95.94
Molecular weight 430.25
XLogP 5.49
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Angiotensin-converting enzyme (ACE1) inhibitor for mild to moderate hypertension. Drug treatment provides improved survival following myocardial infarction and congestive heart failure, and also slows progression of renal disease.
Mechanism Of Action and Pharmacodynamic Effects
Converted in the liver to active metabolite trandolaprilat. Inhibits the conversion of angiotensin I to angiotensin II, which in turn decreases blood pressure. Also causes an increase in plasma renin activity.
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