spiraprilat

Ligand id: 6576

Name: spiraprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 157.54
Molecular weight 438.13
XLogP 4.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Prodrug spirapril is used in the treatment of hypertension and congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. This in turn reduces the vasoconstrictive effects of angiotensin II leading to a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms leading to decreased vasopressor activity and decreased aldosterone secretion.