eptifibatide

Ligand id: 6585

Name: eptifibatide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 20
Hydrogen bond donors 11
Rotatable bonds 11
Topological polar surface area 374.49
Molecular weight 831.32
XLogP 0.89
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Eptifibatide is administered with aspirin and unfractionated heparin (other anti-thrombotic drugs) to prevent myocardial infarction in high risk patients, such as those experiencing acute angina.
Mechanism Of Action and Pharmacodynamic Effects
Eptifibatide inhibits platelet aggregation by binding to platelet receptor glycoprotein (integrin αIIb/β3 complex), thus preventing the binding of clot forming components such as fibrinogen, von Willebrand factor, and other adhesive ligands.