pimecrolimus

Ligand id: 6783

Name: pimecrolimus

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 158.13
Molecular weight 809.45
XLogP 4.42
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used topically to treat atopic dermatitis (eczema)
Mechanism Of Action and Pharmacodynamic Effects
An immunomodulating agent. Exact mechanism unknown, but may involve inhibition of activating cytokine effects on T cells, and/or inhibition of the release of pro-inflammatory chemicals from mast cells.
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