vincristine

Ligand id: 6785

Name: vincristine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 13
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 171.17
Molecular weight 824.4
XLogP 3.56
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an anti-neoplastic agent in the treatment of leukemia, Hodgkin disease, non-Hodgkin lymphomas, rhabdomyosarcoma, neuroblastoma, Wilms' tumor. Has orphan drug designation by EMA for use to treat acute lymphoblastic leukemia (July 2008).
Mechanism Of Action and Pharmacodynamic Effects
Causes cell cycle arrest by inhibiting microtubule assembly.
External links