clofarabine

Ligand id: 6802

Name: clofarabine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 119.31
Molecular weight 303.05
XLogP -0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat paediatric patients with relapsed or refractory acute lymphoblastic leukemia (ALL) which has failed to respond to at least two other types of treatment.
Mechanism Of Action and Pharmacodynamic Effects
A purine nucleoside antimetabolite. Clofarabine is metabolized by 2'-deoxycytidine kinase (DCK) and is finally phosphorylated to its corresponding triphosphate form in cells. The phosphorylated drug exerts its cttotoxic effects by inhibiting ribonucleotide reductase and DNA polymerases, thereby causing deoxyribonucleotide depletion and inhibition of DNA synthesis.The drug is also used as a substrate by DNA polymerases and is incorporated into DNA causing premature chain termination.
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