Ligand id: 6812

Name: enzalutamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 108.53
Molecular weight 464.09
XLogP 4.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Enzalutamide is used to treat advanced prostate cancer where other treatments have failed or drug resistance has developed. Treatment with enzalutamide delays the time before escalating to chemotherapy by around seventeen months [1].
Mechanism Of Action and Pharmacodynamic Effects
Enzalutamide treatment leads to apoptosis of cancer cells and reduced tumour volume by inhibiting androgen binding to its receptor, androgen receptor nuclear translocation, and subsequent interaction with DNA which culminates in reduced cell proliferation.
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