enzalutamide

Ligand id: 6812

Name: enzalutamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 108.53
Molecular weight 464.09
XLogP 4.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, Iversen P, Bhattacharya S, Carles J, Chowdhury S et al.. (2014)
Enzalutamide in Metastatic Prostate Cancer before Chemotherapy.
N. Engl. J. Med.,  [Epub ahead of print]. [PMID:24881730]
2. Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A et al.. (2009)
Development of a second-generation antiandrogen for treatment of advanced prostate cancer.
Science324 (5928): 787-90. [PMID:19359544]