ethoxzolamide

Ligand id: 6814

Name: ethoxzolamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 118.9
Molecular weight 258.01
XLogP 0.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a diuretic and to treat glaucoma and duodenal ulcers. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Carbonic anhydrase inhibition in the proximal tubules of the kidney underlies the drug's diuretic action, whereas inhibition of carbonic anhydrase in the eye reduces aqueous humor and relieves intraocular hypertension of glaucoma. The drug is believed to inhibit mainly carbonic anhydrase 1.