mycophenolic acid

Ligand id: 6832

Name: mycophenolic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 93.06
Molecular weight 320.13
XLogP 1.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
An immunosuppresant and potent anti-proliferative drug. Used clinically (in triple therapy with calcineurin inhibitors and prednisolone) and in research (to detect cellular xanthine guanine phosphoribosyltransferase expression).
Mechanism Of Action and Pharmacodynamic Effects
Anti-proliferative in T- and B-lymphocytes via inhibition of inosine monophosphate dehydrogenase (IMPDH). Also suppresses antibody formation by B-lymphocytes and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection.