tazarotene

Ligand id: 6952

Name: tazarotene

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 64.49
Molecular weight 351.13
XLogP 6.22
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tazarotene is used to treat various skin disorders such as acne and plaque psoriasis. It is also used to reduce the appearance of wrinkles and skin pigmentation (eg age related mottling and freckles). In the EU, the EMA has granted orphan designation for tazarotene (as Orfagen®) to be used for the treatment of congenital ichthyoses.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of tazarotene action is unknown, but it is suggested that the drug modifies gene expression by acting through the retinoic acid receptor, perhaps acting preferentially through the β and γ isoforms. It also has some affinity for the retinoid X receptors.
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