exemestane

Ligand id: 7073

Name: exemestane

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 34.14
Molecular weight 296.18
XLogP 3.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat estrogen receptor +ve breast cancer in postmenopausal women. Use in premenopausal women (with esstrogen-responsive cancer) is effective if ovarian function is concomittantly suppressed, and this combined therapy is more effective than treatment with tamoxifen plus ovarian suppression [2].
Mechanism Of Action and Pharmacodynamic Effects
Exemestane lowers estrogen levels by inhibiting the cytochrome P450 enzyme (CYP19A1, aka aromatase) which is key to estrogen biosynthesis from androgens.
External links