Ligand id: 7186

Name: fenofibrate

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: fenofibrate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 52.6
Molecular weight 360.11
XLogP 5.29
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to reduce circulating cholesterol and triglyceride levels.
Mechanism Of Action and Pharmacodynamic Effects
Fenofibric acid is an agonist of peroxisome proliferator-activated receptor α (PPARα, PPARA). PPARα is a major regulator of lipid metabolism in the liver. Activating PPARα increases lipolysis and elimination of triglyceride-rich particles from plasma.
Fenofibrate is rapidly hydrolyzed by esterases to the active metabolite, fenofibric acid (first-pass metabolism). Neither fenofibrate nor fenofibric acid are believed to undergo oxidative metabolism (e.g., cytochrome P450) to a significant extent in vivo.
External links