nebivolol

Ligand id: 7246

Name: nebivolol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 70.95
Molecular weight 405.18
XLogP 3.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension and left ventricular failure.
Byvalson® a fixed-dose combination drug containing nebivolol (5mg) and valsartan (80mg; an angiotensin AT1 receptor antagonist) was approved by the FDA in June 2016 for the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Antagonism of β-adrenoceptors prevents the receptors from processing signals from endogenous epinephrine and norepinephrine, resulting in decreased force of heart contractions and lowered heart rate.
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