promazine

Ligand id: 7281

Name: promazine

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View more information in the IUPHAR Pharmacology Education Project: promazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 284.13
XLogP 4.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat moderate to severe psychomotor agitation caused by mental tension and anxiety. This drug also has antiemetic action. All formulations containing promazine hydrochloride appear to have been discontinued in the US.
Mechanism Of Action and Pharmacodynamic Effects
This drug’s molecular mechanism of action (MMOA) is complex, involving antagonism of receptors for several neurotransmitters. The drug's antipsychotic effect is most likely due to antagonism of dopamine and serotonin 5-HT2 receptors. See the DrugBank link for further details.
External links