promethazine

Ligand id: 7282

Name: promethazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 31.78
Molecular weight 284.13
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat insomnia, and may be used as sedative. Also used to treat allergic conditions of the upper respiratory tract and skin.
Mechanism Of Action and Pharmacodynamic Effects
Promethazine blocks the action of endogenous histamine at the histamine H1 receptor. The antiemetic effect may be associated with central anticholinergic actions, with potential activity within the medullary chemoreceptor trigger zone (controls the vomiting center).
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