ticlopidine

Ligand id: 7307

Name: ticlopidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 31.48
Molecular weight 263.05
XLogP 4.08
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Ticlopidine is used to prevent blood clots after a recent heart attack or stroke
Mechanism Of Action and Pharmacodynamic Effects
Ticlopidine antagonises the P2Y purinoceptor 12 (P2RY12), leading to impaired ADP-mediated activation of the integrin αIIbβ3 complex on platelet membranes which normally binds fibrinogen. This action inhibits fibrinogen-induced aggregation of platelets, thereby reducing clot formation.
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