tizanidine

Ligand id: 7308

Name: tizanidine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 90.44
Molecular weight 253.02
XLogP 1.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a muscle relaxant to treat muscle spasticity caused by medical problems such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS, aka motor neorone disease), spastic diplegia, spinal cord injury or disease.
Mechanism Of Action and Pharmacodynamic Effects
Drug action at α2-adrenoceptors increases presynaptic inhibition of motor neurons leading to muscular relaxation. There is evidence from rat studies that the α2B-AR subtype may mediate tizanidine‚Äôs spinal analgesic effect [1-2].
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