tizanidine

Ligand id: 7308

Name: tizanidine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 90.44
Molecular weight 253.02
XLogP 1.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Leiphart JW, Dills CV, Levy RM. (2004)
Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain.
J. Neurosurg.101 (4): 641-7. [PMID:15481719]
2. Ono H, Mishima A, Ono S, Fukuda H, Vasko MR. (1991)
Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.
Neuropharmacology30 (6): 585-9. [PMID:1717870]