Ligand id: 7348

Name: pomalidomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 109.57
Molecular weight 273.07
XLogP -0.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Pomalidomide is approved to treat multiple myeloma.
Mechanism Of Action and Pharmacodynamic Effects
The mechanism of action of this drug is complex. Its immunomodulatory action may involve inhibition of the production of pro-inflammatory cytokines and inhibition of COX2 transcription [6]. See the DrugBank link for more details. The primary target of pomalidomide (and thalidomide) may be the protein cereblon (CRBM, Q96SW2) [3,5], which has been linked to the teratogenic activity of these drugs [1]. Cereblon has multiple actions, including participation in protein ubiquitination complexes and regulation of potassium channels [2].
External links