pomalidomide

Ligand id: 7348

Name: pomalidomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 109.57
Molecular weight 273.07
XLogP -0.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H. (2010)
Identification of a primary target of thalidomide teratogenicity.
Science327 (5971): 1345-50. [PMID:20223979]
2. Jo S, Lee KH, Song S, Jung YK, Park CS. (2005)
Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain.
J. Neurochem.94 (5): 1212-24. [PMID:16045448]
3. Lopez-Girona A, Mendy D, Ito T, Miller K, Gandhi AK, Kang J, Karasawa S, Carmel G, Jackson P, Abbasian M et al.. (2012)
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
Leukemia26 (11): 2326-35. [PMID:22552008]
4. Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G et al.. (2017)
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J. Med. Chem.,  [Epub ahead of print]. [PMID:28425720]
5. Xin W, Xiaohua N, Peilin C, Xin C, Yaqiong S, Qihan W. (2008)
Primary function analysis of human mental retardation related gene CRBN.
Mol. Biol. Rep.35 (2): 251-6. [PMID:17380424]
6. Zhu YX, Kortuem KM, Stewart AK. (2013)
Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma.
Leuk. Lymphoma54 (4): 683-7. [PMID:22966948]